Prefiltration

PreFiber PP + PES

Dual-layer PP + PES membrane cartridge

Bioburden reduction and prefiltration for final membrane cartridges

Dual-layer cartridge: pleated polypropylene depth medium and a 0.1 to 0.65 µm PES membrane. Reduces bioburden ahead of the final membrane filter.

Line: PreFiber · Depth medium (polypropylene or glass microfiber) + PES membrane
Ratings: 0.1 µm to 0.65 µm
Lengths: 10″ · 20″ · 30″ · 40″
Manufacturing: Argentina · ISO 7 cleanroom

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PreFiber PP + PES, dual-layer PP + PES membrane cartridge by Exova

Description

The PreFiber PP + PES is a hybrid filter cartridge that combines two media in a single element: a pleated polypropylene depth medium upstream and a polyethersulfone (PES) membrane as the final filter. Combining depth media and a membrane in one cartridge gives it a high contaminant retention capacity.

It is installed as a prefilter for final membrane filter cartridges: it reduces the microbial load reaching them and extends their service life. It is designed for protein solutions, sera, vaccines, and culture media.

It withstands repeated sanitization cycles with hot water at 80 °C and with cleaning and disinfection chemicals, as well as multiple steam sterilizations at 121 °C, in-line or in an autoclave. This resistance allows the cartridges to be reused. It is manufactured in an ISO 7 cleanroom.

Two media in one cartridge

Pleated polypropylene depth medium upstream and a polyethersulfone (PES) membrane as the final filter.

6,700 cm² per 10″

Nominal filtration area, in lengths from 10″ to 40″ and a 2.75″ (70 mm) diameter.

Pore sizes from 0.1 to 0.65 µm

Four nominal ratings: 0.1, 0.2, 0.45, and 0.65 µm.

Steam at 121 °C, in-line or autoclave

Multiple cycles of 30 to 60 minutes. It can also be sanitized with water at 80 °C, peracetic acid, and sodium hydroxide.

Reusable

Its resistance to repeated sterilization and sanitization cycles allows the cartridges to be reused.

Manufactured in an ISO 7 cleanroom

Materials compliant with FDA 21 CFR 177 for food contact and non-toxic components according to the Argentine Food Code.

Technical specifications

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Materials

Upstream filter medium	Pleated polypropylene depth medium
Downstream filter medium (final filter)	Polyethersulfone (PES) membrane
Outer and inner support layers	Polypropylene
Outer cage, core, and flat ends	Polypropylene
Fin	Polypropylene
Adapter (2-222 and 2-226)	Polypropylene with internal reinforcement
O-rings	Silicone, Viton®, Buna, EPDM, Teflon®-encapsulated Viton®

Dimensions

Nominal filtration area	6,700 cm² per 10″
Nominal length	10″ (254 mm), 20″ (508 mm), 30″ (762 mm), and 40″ (1,016 mm)
Nominal diameter	2.75″ (70 mm)

Operating conditions

Maximum differential pressure	5.5 bar (80 psi) at 25 °C
Maximum differential pressure in reverse flow	0.69 bar (10 psi) at 25 °C
Change-out differential pressure	2 bar

Sterilization and sanitization

Steam sterilization	Multiple cycles of 30 to 60 minutes at 121 °C, in-line or in an autoclave (1)
Hot water sanitization	Multiple cycles of 30 to 60 minutes at 80 °C (1)
Chemical sanitization	Multiple cycles of 30 to 60 minutes with peracetic acid up to 1 % (10,000 ppm), at room temperature
Chemical cleaning	Multiple cycles of 30 to 60 minutes with sodium hydroxide up to 1 % (10,000 ppm) (1)
Note (1)	Recommended only for single-open-end cartridges with internal reinforcement at the 226 / 222 O-ring fitting

Quality and compliance

Materials compliant with FDA 21 CFR 177 for food contact
Complies with European Commission Directive 2002/72/EC on plastic materials in contact with food, with its amendments up to 2008/39/EC
Non-toxic components according to the migration test of the Argentine Food Code and Mercosur SGT3 standards
Manufactured in an ISO 7 cleanroom

Applications

Protein solutions
Sera
Vaccines
Culture media
Protection of final membrane cartridges

Industries

Pharmaceutical and biotech Wine industry SaniFlow filter housings

Frequently asked questions

What filter media does the PreFiber PP + PES have?

Two, in the same element: pleated polypropylene depth media upstream and a polyethersulfone (PES) membrane downstream as the final filter. The support layers, cage, core, and ends are polypropylene.

Can it be steam sterilized?

Yes. It withstands multiple cycles of 30 to 60 minutes at 121 °C, with in-line steam or in an autoclave. This is recommended for single-open-end cartridges with internal reinforcement at the 226 or 222 O-ring fitting.

What differential pressure can it withstand?

Up to 5.5 bar (80 psi) at 25 °C in normal flow and up to 0.69 bar (10 psi) at 25 °C in reverse flow. The change-out differential pressure is 2 bar.

Which chemicals can be used to sanitize and clean it?

Peracetic acid up to 1 % (10,000 ppm) at room temperature and sodium hydroxide up to 1 % (10,000 ppm), in cycles of 30 to 60 minutes. It also withstands hot water at 80 °C.

How does it differ from the PreFiber A PP + PES?

Both combine polypropylene depth media and a PES membrane, with 6,700 cm² per 10″. The PreFiber PP + PES is specified with nominal pore sizes from 0.1 to 0.65 µm; the PreFiber A PP + PES with absolute ratings from 0.1 to 1.2 µm, with the prefilter pore size stated for each.

PreFiber line