Prefiltration

PreFiber GF + PES

Glass microfiber + PES membrane cartridge

Prefiltering biological and protein solutions and beverages before the sterilizing filter

Hybrid cartridge of high-capacity glass microfiber and asymmetric PES membrane, with 6,700 cm² per 10″, for biopharma, beverages, and wine.

Line: PreFiber · Depth medium (polypropylene or glass microfiber) + PES membrane
Ratings: 0.1 µm to 0.6 µm
Lengths: 10″ · 20″ · 30″ · 40″
Manufacturing: Argentina · ISO 7 cleanroom

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PreFiber GF + PES, glass microfiber + PES membrane cartridge by Exova

Description

The PreFiber GF + PES is a hybrid cartridge that integrates a high-capacity glass microfiber (GF) prefilter and a high-flow asymmetric polyethersulfone (PES) final membrane. This combined construction reduces the contaminant load reaching the final filter, prolongs its service life, and lowers the system's operating costs.

It is used to prefilter biological and protein solutions and beverages before final sterilizing filtration. It offers 6,700 cm² of filtration area per 10″, high dirt-holding capacity, and a low pressure drop.

It is designed for the pharmaceutical and biotechnology industry, and for beverages and wine. It is compatible with SIP, CIP, autoclave, and in-line sterilization, and is manufactured in an ISO 7 cleanroom.

Dual GF + PES filter media

High-capacity glass microfiber prefilter and high-flow asymmetric polyethersulfone final membrane.

6,700 cm² per 10″

Nominal filtration area, in standard lengths of 10″, 20″, 30″, and 40″.

High capacity, low pressure drop

Optimized to protect downstream sterilizing-grade filters.

SIP, CIP, and autoclave

Steam at 121 °C in-line or in an autoclave; hot water at 80 °C; peracetic acid and sodium hydroxide up to 1 %.

Biopharma, beverages, and wine

Protein solutions, buffers, culture media, large-volume parenterals, wine, beer, cider, and juices.

Manufactured in an ISO 7 cleanroom

Materials compliant with FDA 21 CFR 177 for food contact and non-toxic components according to the Argentine Food Code.

Technical specifications

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Materials

Upstream filter medium	High-capacity glass microfiber
Downstream filter medium (final filter)	Asymmetric polyethersulfone (PES) membrane
Outer and inner support layers	Polypropylene
Outer cage, core, and flat ends	Polypropylene
Fin	Polypropylene
Adapter (222 and 226)	Polypropylene with internal reinforcement
O-rings	Silicone, Viton®, Buna, EPDM, Teflon®-encapsulated Viton®

Dimensions

Nominal filtration area	6,700 cm² per 10″
Nominal length	10″ (254 mm), 20″ (508 mm), 30″ (762 mm), and 40″ (1,016 mm)
Nominal diameter	2.75″ (70 mm)

Operating conditions

Maximum differential pressure	5.5 bar (80 psi) at 25 °C
Maximum differential pressure in reverse flow	0.69 bar (10 psi) at 25 °C
Recommended change-out differential pressure	2 bar

Sterilization and sanitization

Compatibility	SIP, CIP, autoclave, and in-line sterilization
Steam sterilization	Multiple cycles of 30 to 60 minutes at 121 °C, in-line or in an autoclave (1)
Hot water sanitization	Multiple cycles of 30 to 60 minutes at 80 °C (1)
Chemical sanitization	Multiple cycles of 30 to 60 minutes with peracetic acid up to 1 % (10,000 ppm), at room temperature
Chemical cleaning	Multiple cycles of 30 to 60 minutes with sodium hydroxide up to 1 % (10,000 ppm) (1)
Note (1)	Recommended only for single-open-end cartridges with internal reinforcement at the 226 / 222 O-ring fitting

Quality and compliance

Materials compliant with FDA 21 CFR 177 for food contact
Complies with European Commission Directive 2002/72/EC on plastic materials in contact with food, with its amendments up to 2008/39/EC
Non-toxic components according to the migration test of the Argentine Food Code and Mercosur SGT3 standards
Manufactured in an ISO 7 cleanroom

Applications

Clarification of protein solutions
Pretreatment of buffers and media
Serum
Large-volume parenterals
Culture media
Filtration ahead of final membranes in wine
Clarification of beer, cider, and juices
Protection of final membrane filters

Industries

Pharmaceutical and biotech Food and beverage Wine industry SaniFlow filter housings

Frequently asked questions

What layers does the PreFiber GF + PES have?

A high-capacity glass microfiber prefilter upstream and an asymmetric polyethersulfone (PES) membrane downstream. The support layers, cage, core, and ends are polypropylene.

What pore sizes and lengths are available?

Pore sizes of 0.1, 0.2, 0.4, and 0.6 µm; lengths of 10″, 20″, 30″, and 40″; a 2.75″ (70 mm) diameter.

Can it be steam sterilized in-line?

Yes. It withstands multiple cycles of 30 to 60 minutes with in-line steam or in an autoclave at 121 °C. This is recommended for single-open-end cartridges with internal reinforcement at the 226 or 222 O-ring fitting.

Is it suitable for wine and other beverages?

Yes. Its applications include filtration ahead of final membranes in wine and clarification of beer, cider, and juices. Its materials are compliant with FDA 21 CFR 177 for food contact.

What sets it apart from the PreFiber Max GF + PES?

Both combine glass microfiber and an asymmetric PES membrane. The PreFiber GF + PES uses high-capacity glass, with 6,700 cm² per 10″ and a low pressure drop; the PreFiber Max GF + PES uses a high-density glass prefilter, for heavy particle and colloid loads, with 4,500 cm² per 10″.

PreFiber line