Single-use and bioprocessing

AgileConnect Closure and Fastening

Pinch clamps, sleeve and ties

Pinch clamps, metal sleeve, and nylon cable ties to close off and secure tubing lines

Polypropylene pinch clamps, an AISI 304 stainless steel sleeve to pinch off tubing, and nylon 6/6 cable ties to close off and secure single-use lines.

Line: AgileConnect · Pharmaceutical-grade polypropylene, polysulfone, and silicone

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AgileConnect Closure and Fastening, pinch clamps, sleeve and ties by Exova

Description

Three AgileConnect accessories for closing off and securing the tubing lines of a single-use system.

The pinch clamps (P1 to P3) close off tubing temporarily or permanently to control flow without disconnecting the line, maintaining system integrity. They are made of pharmaceutical-grade polypropylene, are lightweight and easy to handle even with gloves, and close without damaging the tubing. They are available for silicone and TPE tubing up to 1/4″, 1/2″, and 3/4″.

The metal sleeve (MS1), made of AISI 304 stainless steel, shuts off silicone or TPE tubing securely and permanently, with no risk of accidental reopening. It replaces plastic clamps where more strength is needed, can be combined with welding or permanent sealing systems, and is autoclavable and resistant to CIP/SIP cleaning.

The nylon 6/6 cable ties (PREC-1 to PREC-3) secure tubing on hose barb connections, organize lines on manifolds or racks, and fasten bags, sensors, and accessories to the frame. They are self-locking and free of halogens, TSE/BSE, and phthalates.

Shut off without disconnecting

The pinch clamps control the flow in a line without disconnecting it, temporarily or permanently.

USP Class VI pinch clamps

Polypropylene compliant with USP <88> Class VI, USP <87> (cytotoxicity), and USP <85> (endotoxins).

AISI 304 stainless steel sleeve

Permanent pinch-off, with no risk of accidental reopening. Autoclavable and resistant to CIP/SIP cleaning.

Nylon 6/6 cable ties

Self-locking; free of halogens, TSE/BSE, and phthalates. Three lengths, for 1/8″ to 3/8″ tubing.

For silicone and TPE

Pinch clamps and metal sleeve for the flexible tubing of single-use systems.

Technical specifications

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Pinch clamps

Material	Pharmaceutical-grade polypropylene
Tubing	Silicone and TPE, up to 1/4″ (P1), 1/2″ (P2), and 3/4″ (P3)
Sterilization	Autoclave or gamma irradiation at 25 to 45 kGy
Packaging	Double bag, for entry into ISO 7 or 8 areas

Metal sleeve

Material	AISI 304 stainless steel
Tubing	Flexible silicone and TPE, various sizes
Sterilization	Autoclave or gamma irradiation; resistant to CIP/SIP cleaning
Finish	Smooth surface, no sharp edges, suitable for GMP use

Cable ties

Material	Nylon 6/6, blue
Closure	Self-locking
Resistance	To chemicals and moisture

Quality and compliance

Pinch clamps: USP <88> Class VI, USP <87> (cytotoxicity), and USP <85> (endotoxins)
Metal sleeve: smooth surface, no sharp edges, suitable for GMP use
Cable ties: free of halogens, TSE/BSE, and phthalates; suitable for GMP environments and ISO 7 cleanrooms

Selection data

Pinch clamps
Part number	Tubing	Material	Sterilization
P1	Up to 1/4″	Polypropylene	Autoclave or gamma
P2	Up to 1/2″	Polypropylene	Autoclave or gamma
P3	Up to 3/4″	Polypropylene	Autoclave or gamma

Standard pack: 10 units per part number.

Metal sleeve
Part number	Tubing	Material	Sterilization
MS1	Flexible, various sizes	AISI 304 stainless steel	Autoclave or gamma

Standard pack: 10 units.

Nylon cable ties
Part number	Length × width	Tubing	Pack
PREC-1	100 × 2.4 mm	1/8″ ID	Bag of 100
PREC-2	150 × 3.6 mm	1/4″ ID	Bag of 100
PREC-3	200 × 4.8 mm	3/8″ ID	Bag of 100

Nylon 6/6, blue.

Applications

Controlled shut-off of process lines
Fluid sampling or segmentation
Permanent pinch-off of lines in manifolds
Sealing of purge or sampling lines
Closure validation and process simulations
Securing tubing and organizing lines on manifolds or racks

Industries

Pharmaceutical and biotech

Frequently asked questions

Pinch clamp or metal sleeve?

The pinch clamp closes off tubing temporarily or permanently to control flow without disconnecting the line. The metal sleeve is for permanent closure, with no risk of accidental reopening, where more strength, durability, or safety is needed than a plastic clamp provides.

Which cable tie goes with each tubing size?

PREC-1 (100 × 2.4 mm) for tubing with a 1/8″ inner diameter, PREC-2 (150 × 3.6 mm) for 1/4″, and PREC-3 (200 × 4.8 mm) for 3/8″. They come in bags of 100.

Can they be sterilized?

The pinch clamps and the metal sleeve, in an autoclave or by gamma irradiation; the sleeve also withstands CIP/SIP cleaning. The cable tie catalog does not specify sterilization: they are designed for GMP environments and ISO 7 cleanrooms.

AgileConnect line