Membrane cartridges

LifePure Plus

Extended-area PES membrane cartridge

Microorganism control and particle removal with an extended filtration area

Asymmetric PES membrane filter cartridge from 0.1 to 1.2 µm with 9,000 cm² per 10″, for controlling microorganisms in pharmaceutical and industrial processes.

Line: LifePure · Polyethersulfone (PES)
Pore sizes: 0.1 µm to 1.2 µm
Lengths: 10″ · 20″ · 30″ · 40″
Manufacturing: Argentina · ISO 7 cleanroom

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LifePure Plus, extended-area PES membrane cartridge by Exova

Description

The LifePure Plus is an asymmetric polyethersulfone (PES) membrane filter cartridge for controlling microorganisms and removing particles in industrial processes. Its uses include parenteral and ophthalmic solutions, sera and blood products, biological products, culture media, and water treatment.

The membrane has open pores on the outer face that narrow down to the final pore of the filter. With its extended filtration area of 9,000 cm² per 10″, it allows high flow rates with low pressure drop and has a high contaminant retention capacity. There are six ratings, from 0.1 to 1.2 µm; the 0.1 µm rating also retains Acholeplasma laidlawii.

It withstands repeated sanitization cycles with hot water at 80 °C and with chemical cleaning and disinfection agents, as well as multiple steam sterilizations in-line or in an autoclave. This resistance allows the cartridge to be reused.

9,000 cm² per 10″

Extended filtration area with an asymmetric membrane: high flow rates, low pressure drop, and high retention.

Sterilizing retention at 0.1 and 0.2 µm

More than 10⁷ Brevundimonas diminuta per cm², according to the FDA definition of sterilizing-grade filters.

Acholeplasma laidlawii retention

The 0.1 µm rating retains more than 10⁴ Acholeplasma laidlawii per cm².

Steam, hot water, and chemicals

Cycles of 30 to 60 minutes with steam at 121 °C, water at 80 °C, peracetic acid, or sodium hydroxide at 1 %.

Manufactured in an ISO 7 cleanroom

Materials compliant with FDA 21 CFR 177 and with European Directive 2002/72/EC.

Microbial retention

Values stated in the LifePure Plus catalog.

0.1 µm > 10⁴ /cm² Acholeplasma laidlawii

0.1 µm and 0.2 µm > 10⁷ /cm² Brevundimonas diminuta According to the FDA definition of sterilizing-grade filters

0.45 µm > 10⁷ /cm² Serratia marcescens

0.65 µm > 10⁷ /cm² Saccharomyces cerevisiae

Technical specifications

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Materials

Filter medium	Asymmetric polyethersulfone (PES)
Outer support layer	Polypropylene
Inner support layer	Polypropylene
Outer cage	Polypropylene
Core	Polypropylene
Flat ends	Polypropylene
Fin	Polypropylene
Adapter (222 and 226)	Polypropylene with internal reinforcement
O-rings	Silicone, Viton, Buna, EPDM, PTFE-encapsulated Viton

Dimensions

Nominal filtration area	9,000 cm² per 10″
Nominal length	10″ (254 mm), 20″ (508 mm), 30″ (762 mm), and 40″ (1,016 mm)
Nominal diameter	2.75″ (70 mm)

Operating conditions

Maximum differential pressure	5.5 bar (80 psi) at 25 °C
Maximum differential pressure in reverse flow	0.69 bar (10 psi) at 25 °C
Maximum differential pressure for change-out	2 bar

Sterilization and sanitization

Steam sterilization	Multiple cycles of 30 to 60 minutes at 121 °C, in-line or in an autoclave
Hot water sanitization	Multiple cycles of 30 to 60 minutes with water at 80 °C
Chemical sanitization	Multiple cycles of 30 to 60 minutes with peracetic acid, maximum concentration 1 % (10,000 ppm), at room temperature
Chemical cleaning	Multiple cycles of 30 to 60 minutes with sodium hydroxide, maximum concentration 1 % (10,000 ppm)
Recommendation	Steam, hot water, and sodium hydroxide: only for single-open-end cartridges with internal reinforcement at the 226 / 222 O-ring fitting

Quality and compliance

Materials compliant with FDA 21 CFR 177 for food contact
Complies with European Commission Directive 2002/72/EC and its amendments up to 2008/39/EC
Manufactured in an ISO 7 cleanroom

Applications

Parenteral solutions
Ophthalmic solutions
Sera and blood products
Biological products
Culture media
Veterinary pharmaceutical solutions
Water treatment
Prefiltration ahead of final filters

Industries

Pharmaceutical and biotech Water treatment SaniFlow filter housings

Frequently asked questions

Which rating retains Acholeplasma laidlawii?

The 0.1 µm rating, with more than 10⁴ Acholeplasma laidlawii per cm². The 0.1 and 0.2 µm ratings also retain more than 10⁷ Brevundimonas diminuta per cm², according to the FDA definition of sterilizing-grade filters.

What filtration area does it have?

9,000 cm² per 10″, in 10″, 20″, 30″, and 40″ cartridges with a 2.75″ (70 mm) diameter.

Can it be steam-sterilized?

Yes. It withstands multiple cycles of 30 to 60 minutes at 121 °C, in-line or in an autoclave. The catalog recommends it for single-open-end cartridges (configurations B to E).

What differential pressure does it withstand?

Up to 5.5 bar (80 psi) at 25 °C in the forward direction and 0.69 bar (10 psi) at 25 °C in reverse flow. The maximum differential pressure for cartridge change-out is 2 bar.

LifePure line